Optimizing NMN supplementation requires strategic dosing and administration:
· Dosage Guidelines:
· Maintenance: 250–500 mg daily (1–2 doses) 35.
· Therapeutic Use: 500–1,000 mg daily, split into 2–4 doses 110.
Do not exceed 1,000 mg without medical supervision.
· Administration:
· Sublingual: Place 1⁄4–1⁄2 tsp under the tongue for 60–90 seconds. This bypasses gastric breakdown, accelerating absorption 10.
· Dissolved in Water: Consume on an empty stomach upon waking 4.
Avoid mixing with hot beverages to preserve molecular integrity.
· Timing: Morning or pre-workout doses align with natural NAD+ cycles. Avoid late-evening doses to prevent sleep disruption.
· Safety:
· No severe side effects are documented at recommended doses. Mild gastrointestinal discomfort may occur initially 3.
· Contraindicated during pregnancy, breastfeeding, or for those with chronic illnesses (e.g., cancer) 10.
· Consult a physician if using diabetes or blood-pressure medications.
Consistency is critical—effects like reduced fatigue and improved metabolism manifest after 4–12 weeks 5
